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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MRE11A All Species: 34.55
Human Site: Y82 Identified Species: 54.29
UniProt: P49959 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49959 NP_005581.2 708 80593 Y82 C L E L L R K Y C M G D R P V
Chimpanzee Pan troglodytes XP_001142343 708 80653 Y82 C L E L L R K Y C M G D R P V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542244 708 80700 Y82 C L E L L R K Y C M G D R P V
Cat Felis silvestris
Mouse Mus musculus Q61216 706 80204 Y82 C L E L L R K Y C M G D R P V
Rat Rattus norvegicus Q9JIM0 706 80103 Y82 C L E L L R K Y C M G D R P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513434 706 80323 Y82 C L E L L R K Y C M G D R P I
Chicken Gallus gallus Q9IAM7 700 80005 Y82 C L E S L R K Y C M G D R P V
Frog Xenopus laevis Q9W6K1 711 81112 Y83 C L E Q L R K Y C M G D R P I
Zebra Danio Brachydanio rerio NP_001001407 619 70401 S69 L F H D N K P S R K T M H S C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_523547 620 69267 S70 L F H D A V P S Q N A L H K C
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23255 728 81540 Y135 V T Q L L R Q Y C L N G N P I
Sea Urchin Strong. purpuratus XP_798167 515 58684
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XGM2 720 80272 H79 A I E I L R R H C L N D K P V
Baker's Yeast Sacchar. cerevisiae P32829 692 77632 C78 V L K T L R L C C M G D K P C
Red Bread Mold Neurospora crassa Q9C291 739 83526 K77 Q V M R S L R K H C L G M K P
Conservation
Percent
Protein Identity: 100 99.4 N.A. 93.7 N.A. 88.2 88.4 N.A. 85 73.5 72.8 61.2 N.A. 39.5 N.A. 32.6 42.6
Protein Similarity: 100 99.4 N.A. 97.1 N.A. 93.7 93.7 N.A. 92.3 85.5 85 75.2 N.A. 55.6 N.A. 50.6 56.9
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 93.3 93.3 86.6 0 N.A. 0 N.A. 40 0
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 93.3 93.3 6.6 N.A. 0 N.A. 66.6 0
Percent
Protein Identity: N.A. N.A. N.A. 38.1 35.3 33.8
Protein Similarity: N.A. N.A. N.A. 57.9 53.3 52.5
P-Site Identity: N.A. N.A. N.A. 46.6 53.3 0
P-Site Similarity: N.A. N.A. N.A. 86.6 66.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 7 0 0 0 0 0 7 0 0 0 0 % A
% Cys: 54 0 0 0 0 0 0 7 74 7 0 0 0 0 20 % C
% Asp: 0 0 0 14 0 0 0 0 0 0 0 67 0 0 0 % D
% Glu: 0 0 60 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 60 14 0 0 0 % G
% His: 0 0 14 0 0 0 0 7 7 0 0 0 14 0 0 % H
% Ile: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 20 % I
% Lys: 0 0 7 0 0 7 54 7 0 7 0 0 14 14 0 % K
% Leu: 14 60 0 47 74 7 7 0 0 14 7 7 0 0 0 % L
% Met: 0 0 7 0 0 0 0 0 0 60 0 7 7 0 0 % M
% Asn: 0 0 0 0 7 0 0 0 0 7 14 0 7 0 0 % N
% Pro: 0 0 0 0 0 0 14 0 0 0 0 0 0 74 7 % P
% Gln: 7 0 7 7 0 0 7 0 7 0 0 0 0 0 0 % Q
% Arg: 0 0 0 7 0 74 14 0 7 0 0 0 54 0 0 % R
% Ser: 0 0 0 7 7 0 0 14 0 0 0 0 0 7 0 % S
% Thr: 0 7 0 7 0 0 0 0 0 0 7 0 0 0 0 % T
% Val: 14 7 0 0 0 7 0 0 0 0 0 0 0 0 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 60 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _